兰索拉唑胶囊（Lansoprazole Capsules）.docVIP

兰索拉唑胶囊（Lansoprazole Capsules） [Lansoprazole Capsules] common name Name used before English name LANSOPRAZOLE CAPSULES Pinyin: LANSUOLAZUO JIAONANG [Specification] (1) 15mg (2) 30mg [category] antiacids and drugs of anti ulcer drugs [properties] this product is white capsules, the contents for the white or white coated spherical particles. [] the drug pharmacology and toxicology transfer to the parietal cells of the gastric mucosa of the acid secretion of straw, in acidic conditions, converted to the active structure, the active substance with a proton pump ((H+ + K+) -ATPase) SH binding, which inhibit the enzyme activity, which can inhibit gastric acid secretion. 1. (H+K+) -ATPase inhibitory effect of lansoprazole can inhibit dog gastric mucosa microsomes (H+K+) activity of -ATPase (in vitro). 2. cell wall acid inhibitory effect of lansoprazole on gastric mucosa from dog parietal cells by histamine, acetylcholine and gastrin produced by stimulation of acid secretion, has inhibitory effect (in vitro). 3. gastric acid secretion inhibition of 1) on the secretion of gastrin stimulated acid: in healthy adults, 1 days 1 30mg lansoprazole orally administered for 7 consecutive days, inhibited by gastrin induced acid secretion, and this effect can last 24 hours. 2) caused by the stimulation of insulin on the secretion of acid in healthy adults, 1 days 1 30mg lansoprazole orally administered for 7 consecutive days, can be inhibited by insulin induced acid secretion. 3) on the secretion of nocturnal acid: in healthy adults, 1 days 1 30mg lansoprazole orally administered for 7 consecutive days, significantly suppressed nocturnal gastric acid secretion. 4) on the secretion of acid: 24 hours in healthy adults 24 hours gastric sampling test in 1 days, 1 times of lansoprazole oral administration of 30mg for 7 days, 24 hours significantly inhibited gastric acid secretion. 5) 24 hour intragastric pH monitoring: in healthy adults and patients with duodenal ulcer, 1 to 1 days of lansop