萘普生钠片（naproxen sodium tablets）.docVIP

萘普生钠片（naproxen sodium tablets） The common name of Naproxen Sodium Tablets Name used before English name NAPROXEN SODIUM TABLETS Pinyin name NAIPUSHENGNA PIAN Antipyretic, analgesic and non steroidal anti-inflammatory and analgesic drugs Character white or white like. Pharmacologically, naproxen has a dose-dependent anti-inflammatory, analgesic, and antipyretic effects. The intensity is about 11 times the anti-inflammatory effects of doses of phenylbutazone, antipyretic analgesic, aspirin is 7 times and 22 times. The anti-inflammatory, analgesic and antipyretic effects were equivalent to indomethacin. The mechanism of action is that naproxen acts by inhibiting the activity of COX and inhibiting the synthesis of PG, but the selective inhibition of COX2 is stronger, so the anti-inflammatory effect is stronger, and the adverse reaction of gastrointestinal tract is smaller. Pharmacokinetics, naproxen, free acid and sodium salt were applied with an equivalent dose of 1:1.1. After oral administration, it is easy to absorb from the stomach and intestines, and it is complete, but the absorption rate of sodium salt is faster. The peak concentration of serum reaches 1 hours after taking the medicine, and the free acid takes 2 hours. Gastric content prolonged the absorption time, but did not affect the absorption rate. The binding rate of plasma protein was high ( 99.5%). Can be distributed in all tissues, synovial fluid in the effective concentration, and can enter the fetus through the placenta. Metabolism by the liver, kidney excretion, excretion of most of the metabolites, a small amount of the prototype. About 3% excreted from feces, and 1% secreted milk. Plasma t1/2 was 13 hours. This product can also be given to the rectum, but the absorption rate is slower than oral. Indications: This product is non steroidal anti-inflammatory drugs. Apply to relieve all kinds of mild to moderate pain, such as pain after extraction and other operations, primary dysmenorrhea and headache