乳腺癌的治疗方法内分泌治疗（Treatment of breast cancer, endocrine therapy）.doc

乳腺癌的治疗方法内分泌治疗（Treatment of breast cancer, endocrine therapy） Treatment of breast cancer, endocrine therapy The treatment of breast cancer, endocrine therapy has been for more than a hundred years. Endocrine therapy for breast cancer is the most mature and effective in endocrine therapy of breast cancer. The rise of estrogen levels in the body is a major factor in the proliferation of breast cancer cells. Estrogen is secreted mainly by the ovaries of women before menopause and is secreted by the adrenal glands and parts of the adipose tissue after menopause. Estrogen and progesterone receptors are present in breast cells, which cause mammary glands to proliferate with hormone levels. Research shows that about 2/3 of breast cancer cells contain a certain amount of estrogen receptor (estrogen receptor, ER), this type of breast cancer called ER estrogen receptor positive breast cancer; 40-50% breast cancer containing progesterone receptor (progesterone receptor, PR), this type of breast cancer called PR pregnant hormone receptor positive breast cancer. ER estrogen receptor or PR progesterone receptor positive breast cancer is sensitive to hormone therapy. At present, the endocrine therapy to object to the ER or PR progesterone receptor positive tumors, slow growth, long disease-free survival after surgery, with or without bone and soft tissue metastasis, asymptomatic visceral metastases and previous effective endocrine therapy in breast cancer patients. For patients with receptor positive breast cancer, most patients are now expected to have chemotherapy and endocrine therapy. However, in the past two treatment time controversial, in recent years a large clinical trial results showed that endocrine therapy after chemotherapy and radiotherapy should be started, one can improve the survival of patients with breast cancer, on the other hand can increase the effect of chemotherapy. Endocrine therapy for different duration is different, the commonly used tamoxifen (tamoxifen