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a mouse-adapted sars-coronavirus causes disease and mortality in balbc micemouse-adapted发热导致疾病和死亡率balbc老鼠.pdf

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a mouse-adapted sars-coronavirus causes disease and mortality in balbc micemouse-adapted发热导致疾病和死亡率balbc老鼠

A Mouse-Adapted SARS-Coronavirus Causes Disease and Mortality in BALB/c Mice 1 2 3 1 4 1 Anjeanette Roberts , Damon Deming , Christopher D. Paddock , Aaron Cheng , Boyd Yount , Leatrice Vogel , Brian D. Herman1 2 2,5,6 3 3 2,4,5 1* , Tim Sheahan , Mark Heise , Gillian L. Genrich , Sherif R. Zaki , Ralph Baric , Kanta Subbarao 1 Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, 2 Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America, 3 Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America, 4 Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America, 5 Carolina Vaccine Institute, University of North Carolina, Chapel Hill, North Carolina, United States of America, 6 Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America No single animal model for severe acute respiratory syndrome (SARS) reproduces all aspects of the human disease. Young inbred mice support SARS-coronavirus (SARS-CoV) replication in the respiratory tract and are available in sufficient numbers for statistical evaluation. They are relatively inexpensive and easily accessible, but their use in SARS research is limited because they do not develop illness following infection. Older (12- to 14-mo-old) BALB/c mice develop clinical illness and pneumoniti