a murine model to study the antibacterial effect of copper on infectivity of salmonella enterica serovar typhimurium抗菌效果的小鼠模型来研究铜鼠伤寒沙门氏菌血清型的传染性.pdfVIP

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a murine model to study the antibacterial effect of copper on infectivity of salmonella enterica serovar typhimurium抗菌效果的小鼠模型来研究铜鼠伤寒沙门氏菌血清型的传染性.pdf

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a murine model to study the antibacterial effect of copper on infectivity of salmonella enterica serovar typhimurium抗菌效果的小鼠模型来研究铜鼠伤寒沙门氏菌血清型的传染性

Int. J. Environ. Res. Public Health 2011, 8, 21-36; doi:10.3390/ijerph8010021 OPEN ACCESS International Journal of Environmental Research and Public Health ISSN 1660-4601 /journal/ijerph Article A Murine Model to Study the Antibacterial Effect of Copper on Infectivity of Salmonella Enterica Serovar Typhimurium Riti Sharan 1,*, Sanjay Chhibber 2 and Robert H. Reed 1 1 Centre for Plant and Water Science, Faculty of Sciences, Engineering and Health, CQ University, Rockhampton, Queensland 4702, Australia; E-Mail: r.reed@.au 2 Department of Microbiology, Panjab University, Chandigarh 160014, India; E-Mail: sanjaychhibber8@ * Author to whom correspondence should be addressed; E-Mail: talktoriti@; Tel.: +91-99152-84773. Received: 6 November 2010; in revised form: 16 December 2010 / Accepted: 22 December 2010 / Published: 24 December 2010 Abstract: This study investigated the effect of copper as an antibacterial agent on the infectivity of Salmonella enterica serovar Typhimurium. Mice were infected orally with a standardized dose of unstressed Salmonella Typhimurium and copper-stressed cells of Salmonella Typhimurium. Bacterial counts in ileum, blood, liver and spleen were observed up to 168 h under normal aerobic conditions. Serum sensitivity, phagocytosis, malondialdehyde levels and hi