a novel modular antigen delivery system for immuno targeting of human 6-sulfo lacnac-positive blood dendritic cells (slandcs)一种新的模块化免疫抗原递送系统针对人类6-sulfo lacnac-positive血树突状细胞(slandcs).pdfVIP

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a novel modular antigen delivery system for immuno targeting of human 6-sulfo lacnac-positive blood dendritic cells (slandcs)一种新的模块化免疫抗原递送系统针对人类6-sulfo lacnac-positive血树突状细胞(slandcs).pdf

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a novel modular antigen delivery system for immuno targeting of human 6-sulfo lacnac-positive blood dendritic cells (slandcs)一种新的模块化免疫抗原递送系统针对人类6-sulfo lacnac-positive血树突状细胞(slandcs)

A Novel Modular Antigen Delivery System for Immuno Targeting of Human 6-sulfo LacNAc-Positive Blood Dendritic Cells (SlanDCs) 1 1 1 1 1 Claudia C. Bippes , Anja Feldmann , Slava Stamova , Marc Cartellieri , Adrian Schwarzer , Rebekka 1 1,2 1 1,3 ¨ 1 1 Wehner , Marc Schmitz , E. Peter Rieber , Senming Zhao , Knut Schakel , Achim Temme , R. Hal 4 4 1 1,2 Scofield , Biji T. Kurien , Holger Bartsch , Michael Bachmann * 1 Institute of Immunology, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany, 2 Center for Regenerative Therapies Dresden, Technical University Dresden, Dresden, Germany, 3 Third Hospital of Hebei Medical University, Hebei, China, 4 Oklahoma Medical Research Foundation (OMRF), Oklahoma City, Oklahoma, United States of America Abstract Background: Previously, we identified a major myeloid-derived proinflammatory subpopulation of human blood dendritic ¨ cells which we termed slanDCs (e.g. Schakel et al. (2006) Immunity 24, 767–777). The slan epitope is an O-linked sugar modification (6-sulfo LacNAc, slan) of P-selectin glycoprotein ligand-1 (PSGL-1). As slanDCs can induce neoantigen-specific CD4+ T cells and tumor-reactive CD8+ cytotoxic T cells, they appear as promising targets for an in vivo delivery of antigens for vaccination. However, tools for delivery of antigens to slanDCs were not available until now. Moreover, it is unknown whether or not antigens delive