a novel molecular solution for ultraviolet light detection in caenorhabditis elegans一种新型分子在秀丽隐杆线虫紫外线检测解决方案.pdfVIP
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a novel molecular solution for ultraviolet light detection in caenorhabditis elegans一种新型分子在秀丽隐杆线虫紫外线检测解决方案
PLoS BIOLOGY
A Novel Molecular Solution for Ultraviolet
Light Detection in Caenorhabditis elegans
Stacey L. Edwards, Nicole K. Charlie, Marie C. Milfort, Brandon S. Brown, Christen N. Gravlin, Jamie E. Knecht,
*
Kenneth G. Miller
Genetic Models of Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
For many organisms the ability to transduce light into cellular signals is crucial for survival. Light stimulates DNA repair
and metabolism changes in bacteria, avoidance responses in single-cell organisms, attraction responses in plants, and
both visual and nonvisual perception in animals. Despite these widely differing responses, in all of nature there are
only six known families of proteins that can transduce light. Although the roundworm Caenorhabditis elegans has none
of the known light transduction systems, we show here that C. elegans strongly accelerates its locomotion in response
to blue or shorter wavelengths of light, with maximal responsiveness to ultraviolet light. Our data suggest that C.
elegans uses this light response to escape the lethal doses of sunlight that permeate its habitat. Short-wavelength light
drives locomotion by bypassing two critical signals, cyclic adenosine monophosphate (cAMP) and diacylglycerol (DAG),
that neurons use to shape and control behaviors. C. elegans mutants lacking these signals are paralyzed and
unresponsive to harsh physical stimuli in ambient light, but short-wavelength light rapidly rescues their paralysis and
restores normal levels of coordinated locomotion. This light response is mediated by LITE-1, a novel ultraviolet light
receptor that acts in neurons and is a member of the invertebrate Gustatory receptor (Gr) family.
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