-突触核蛋白与帕金森病.doc

α-突触核蛋白与帕金森病 国外医学?老年医学分册2007年11月第28卷第6期 LRRK2causeautosomaldominantparkinsonismwithpleo- morphicpathology.Neuron,2004;44(4):601—607 Paisan—RuizC,JainS,EvansEWeto1.Cloningofthe genecontainingmutationsthatcausePARK8—-linkedPar? klnsonsdisease.Neuron,2004;44(4):595—600 MataIF,RossOA,KachergusJeta1.LRRK2mutations areacommoncauseofParkinsonsdiseaseinSpain.Eur JNeurol,2006;13(4):391—394 ClarkLN,WangY,KarlinsEeta1.FrequencyofLRRK2 mutationsinearlyandlate—onsetParkinsondisease. Neurology,2006;67:1786—1791 LuCS,ChouYH,WengYHeta1.GeneticandDATima? glngstudiesoffamilialparkinsonlsminaTaiwaneseco- hort.JNeuralTransm,2006;70(Supp1):235—240 HiguchiS,MatsushitaS,NakaneJeta1.Alpha一2mac- roglobulingenepolymorphismsshowracialdiversityand notassociatedwithAlzheimersQdisease.Newreport, 2Ooo:11:1167—1171 ZhangLM,ChenB,FengXLeta1.Polymorphismsof neuralnicotiniccholinergicreceptoralpha4geneofChi- nese.ZhonghuaYiXueChuanXueZaZhi,2006;23 (1):55—58 MawrinC,KirchesE,KrauseGeta1.Region—specifica- OL’’.. ?--—— 249.-——— nalysisofmitochondfialDNAdeletionsinneurodegenera tivedisordersinhumans.NeurosciLett,2o04:357 (2):111—114 24TakahashiT,YamashitaH,NaganoYeta1.Interactions ofSynphilin一1withphospholipidsandlipidmembranes. FEBSLett,2006;580(18):4479—4484 25LuCS,WuChouYH,KuoPCa/.Theparkinsonian phenotypeofspinocerebellarataxiatype2.ArchNeurol, 2004;61(1):35—38 26LuCS,ChangHC,KuoPCeta1.Theparkinsonianphe- notypeofspinocercbellarataxiatype3inaTaiwanesefami- ly.ParkinsonismRelatDisord,2004;10(6):369— 373 27SharmaM,MuellerJC,ZimprichAeta1.Thesepiapterin reductasegeneregionrevealsassociationinthePAK3lo- CUS:analysisoffamilialandsporadicParkinsonsdisease inEuropeanpopulations.JMedGenet,2006;3(7): 557—562 28RamirezA,HeimbachA,GrundemannJeta1.Hereditary ParkinsonlsmwithdementiaiscausedbymutationinA11P 13A2,encodingalysosomaltype5P—typeATPase.Nat Genet,2006;38(10):1184—1191 (2007—03—08收稿) 突触核蛋白与帕金森病 大连医科大学生理学教研室(116027)王晓中综述 解放军第二一.医院刘辉审校 摘要一突触核蛋白是一种在中枢神经系统突触前表达的可溶性蛋白,具有调节膜稳定性和神经可塑性等生理功 能.近来研究发现,一突触核蛋白基因突变及其