原创力文档a pilot study of circulating mirnas as potential biomarkers of early stage breast cancer循环microrna的试点研究早期乳腺癌的潜在生物标志物.pdfVIP
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a pilot study of circulating mirnas as potential biomarkers of early stage breast cancer循环microrna的试点研究早期乳腺癌的潜在生物标志物
A Pilot Study of Circulating miRNAs as Potential
Biomarkers of Early Stage Breast Cancer
1 1 1 2 1 2
Hua Zhao *, Jie Shen , Leonard Medico , Dan Wang , Christine B. Ambrosone , Song Liu *
1 Department of Cancer Prevention and Controls, Roswell Park Cancer Institute, Buffalo, New York, United States of America, 2 Department of Biostatistics, Roswell Park
Cancer Institute, Buffalo, New York, United States of America
Abstract
Background: To date, there are no highly sensitive and specific minimally invasive biomarkers for detection of breast cancer
at an early stage. The occurrence of circulating microRNAs (miRNAs) in blood components (including serum and plasma) has
been repeatedly observed in cancer patients as well as healthy controls. Because of the significance of miRNA in
carcinogenesis, circulating miRNAs in blood may be unique biomarkers for early and minimally invasive diagnosis of human
cancers. The objective of this pilot study was to discover a panel of circulating miRNAs as potential novel breast cancer
biomarkers.
Methodology/Principal Findings: Using microarray-based expression profiling followed by Real-Time quantitative
Polymerase Cycle Reaction (RT-qPCR) validation, we compared the levels of circulating miRNAs in plasma samples from
20 women with early stage breast cancer (10 Caucasian American (CA) and 10 African American (AA)) and 20 matched
healthy controls (10 CAs and 10 AAs). Using the significance level of p ,0.05 constrained by at least two-fold expression
change as selection criteria, we found that 31 miRNAs were differentially expressed in CA study subjects (17 up and 14
down) and 18 miRNAs were differ
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