absence of association between n-acetyltransferase 2 acetylator status and colorectal cancer susceptibility based on evidence from 40 studies之间缺乏联系n-acetyltransferase 2乙酰化器状态和基于证据从40研究大肠癌易感性.pdfVIP

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absence of association between n-acetyltransferase 2 acetylator status and colorectal cancer susceptibility based on evidence from 40 studies之间缺乏联系n-acetyltransferase 2乙酰化器状态和基于证据从40研究大肠癌易感性.pdf

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absence of association between n-acetyltransferase 2 acetylator status and colorectal cancer susceptibility based on evidence from 40 studies之间缺乏联系n-acetyltransferase 2乙酰化器状态和基于证据从40研究大肠癌易感性

Absence of Association between N-Acetyltransferase 2 Acetylator Status and Colorectal Cancer Susceptibility: Based on Evidence from 40 Studies 1,2 . 1. 2 3 4 3 Lou qian Zhang * , Jian nong Zhou , Jun Wang *, Guo dong Liang , Jing ying Li , Yi dan Zhu , Yun tao Su4 1 Colorectal and Anal Surgery Center, The Affiliated Jiangsu Cancer Hospital of Nanjing Medical University, Nanjing, China, 2 Department of Chemotherapy, Jiangsu Geriatric Institute, Jiangsu Official Hospital, Nanjing, China, 3 Department of Gastroenterology, Jiangsu Geriatric Institute, Jiangsu Official Hospital, Nanjing, China, 4 Department of Medical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Abstract Background and Objectives: N-Acetyltransferase (NAT) 2 is an important enzyme involved in the metabolism of different xenobiotics, including potential carcinogens, whose phenotypes were reported to be related to individual susceptibility to colorectal cancer (CRC). However, the results remain conflicting. To assess the relationship between NAT2 phenotypes and CRC risk, we performed this meta-analysis. Methods: A comprehensive literature search was conducted to identify all case-control or cohort studies of NAT2 acetylator status on the susceptibility of CRC by searching of PubMed and EMBASE, up to May 20, 2011. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association. Results: A total of over 40,000 subjects from 40 published literatures were identified by searching the databases. No significantly elevated CRC risk in individuals with NAT2 slow acetylators compared with fast acetylators was found when all studies pooled (OR = 0.95, 95%