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accounting for movement increases sensitivity in detecting brain activity in parkinsons disease占运动增加敏感性在帕金森病检测大脑活动.pdf

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accounting for movement increases sensitivity in detecting brain activity in parkinsons disease占运动增加敏感性在帕金森病检测大脑活动

Accounting for Movement Increases Sensitivity in Detecting Brain Activity in Parkinson’s Disease ˇ 1 ¨ 1 ´ ˇ 2,3 1,4. 2. Stefan Holiga *, Harald E. Moller , Tomas Sieger , Matthias L. Schroeter , Robert Jech , Karsten Mueller1. 1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2 Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, Prague, Czech Republic, 3 Department of Cybernetics, Czech Technical University in Prague, Prague, Czech Republic, 4 Clinic for Cognitive Neurology and Leipzig Research Center for Civilization Diseases, University of Leipzig, and FTLD Consortium, Leipzig, Germany Abstract Parkinson’s disease (PD) is manifested by motor impairment, which may impede the ability to accurately perform motor tasks during functional magnetic resonance imaging (fMRI). Both temporal and amplitude deviations of movement performance affect the blood oxygenation level-dependent (BOLD) response. We present a general approach for assessing PD patients’ movement control employing simultaneously recorded fMRI time series and behavioral data of the patients’ kinematics using MR-compatible gloves. Twelve male patients with advanced PD were examined with fMRI at 1.5T during epoch-based visually paced finger tapping. MR-compatible gloves were utilized online to quantify motor outcome in two conditions with or without dopaminergic medication. Modeling of individual-level brain activity included (i) a predictor consisting of a condition-specific, constant-amplitude