acellular bone marrow extracts significantly enhance engraftment levels of human hematopoietic stem cells in mouse xeno-transplantation models非细胞骨髓提取显著提高移植的人类造血干细胞水平鼠标xeno-transplantation模型.pdfVIP
- 1、本文档共10页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
acellular bone marrow extracts significantly enhance engraftment levels of human hematopoietic stem cells in mouse xeno-transplantation models非细胞骨髓提取显著提高移植的人类造血干细胞水平鼠标xeno-transplantation模型
Acellular Bone Marrow Extracts Significantly Enhance
Engraftment Levels of Human Hematopoietic Stem Cells
in Mouse Xeno-Transplantation Models
1 2 2 3 4
Kazem Zibara , Rima Hamdan , Leila Dib , Steen Sindet-Pedersen , Mohamed Kharfan-Dabaja ,
2,4 2
Ali Bazarbachi *, Marwan El-Sabban *
1 Department of Biology, Doctoral School of Science and Technology (DSST), Lebanese University, Beirut, Lebanon, 2 Department of Anatomy, Cell Biology and
Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon, 3 Department of Oral and Maxillofacial Surgery, Nicolas Asp University
College, Dubai Healthcare City, Dubai, United Arab Emirates, 4 Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
Abstract
Hematopoietic stem cells (HSC) derived from cord blood (CB), bone marrow (BM), or mobilized peripheral blood (PBSC) can
differentiate into multiple lineages such as lymphoid, myeloid, erythroid cells and platelets. The local microenvironment is
critical to the differentiation of HSCs and to the preservation of their phenotype in vivo. This microenvironment comprises a
physical support supplied by the organ matrix as well as tissue specific cytokines, chemokines and growth factors. We
investigated the effects of acellular bovine bone marrow extracts (BME) on HSC in vitro and in vivo. We observed a
significant increase in the number of myeloid and erythroid colonies in CB mononuclear cells (MNC) or CB CD34+ cells
cultured in methylcellulose media supplemented with BME. Similarly, in xeno-transplantation experiments, pretreatment
with BME during ex-v
您可能关注的文档
- a systematic molecular pathology study of a laboratory confirmed h5n1 human case系统的分子病理学研究实验室确认的h5n1禽流感人间病例.pdf
- a systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma系统生物学的方法来描述监管网络导致trabectedin阻力在黏液样脂肪肉瘤的体外模型.pdf
- a systems biology approach to investigating apoptotic stimuli as effectors of cell metabolism practical application of top-down control analysis to attached neurons系统生物学的方法研究凋亡刺激的感受器细胞代谢自上而下控制的实际应用分析神经元连接.pdf
- a systems biology strategy on differential gene expression data discloses some biological features of atrial fibrillation系统生物学策略差异基因表达数据披露的一些生物特征心房纤颤.pdf
- a systems biology approach identifies a r2r3 myb gene subfamily with distinct and overlapping functions in regulation of aliphatic glucosinolates系统生物学的方法识别r2r3 myb基因亚科和独特的脂肪族硫配糖体和重叠的功能调节.pdf
- a systematic screen to discover and analyze apicoplast proteins identifies a conserved and essential protein import factor系统的屏幕上发现和分析apicoplast蛋白质识别守恒的进口因素和必要的蛋白质.pdf
- a systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections系统免疫学方法血浆树突细胞病变病毒感染细胞的功能.pdf
- a tale of four stories soil ecology, theory, evolution and the publication system故事的四个故事土壤生态学、理论、进化和发布系统.pdf
- a t3 and t7 recombinant phage acquires efficient adsorption and a broader host ranget3和t7噬菌体重组获得高效的吸附和更广泛的宿主范围.pdf
- a tale of switched functions from cyclooxygenase inhibition to m-channel modulation in new diphenylamine derivatives切换函数的故事从环氧酶抑制m-channel调制新二苯胺衍生品.pdf
- 2025年辽宁朝阳师范学院招聘急需高层次人才142人笔试模拟试题及答案详解一套.docx
- 接地装置的运行与发热.ppt
- 2018年湖南省娄底市中考数学试题【含答案、解析】.pdf
- 2025年辽宁出入境边防检查总站所属事业单位招聘55人笔试模拟试题及参考答案详解一套.docx
- 2018年湖南省湘西州中考数学试题【含答案、解析】.pdf
- 2025年辽宁大连海洋大学招聘高层次人才31人笔试模拟试题含答案详解.docx
- 2025年辽宁大连金普新区教育系统选聘优秀教师25人笔试模拟试题及完整答案详解1套.docx
- 2025年辽宁大连市甘井子区教育系统自主招聘应届生89人笔试模拟试题附答案详解.docx
- 海船船员考试《狭水管航行找答案》考试题.doc
- 水污染控制及管理课件.pptx
文档评论(0)