a systems biology approach identifies a r2r3 myb gene subfamily with distinct and overlapping functions in regulation of aliphatic glucosinolates系统生物学的方法识别r2r3 myb基因亚科和独特的脂肪族硫配糖体和重叠的功能调节.pdfVIP

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a systems biology approach identifies a r2r3 myb gene subfamily with distinct and overlapping functions in regulation of aliphatic glucosinolates系统生物学的方法识别r2r3 myb基因亚科和独特的脂肪族硫配糖体和重叠的功能调节.pdf

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a systems biology approach identifies a r2r3 myb gene subfamily with distinct and overlapping functions in regulation of aliphatic glucosinolates系统生物学的方法识别r2r3 myb基因亚科和独特的脂肪族硫配糖体和重叠的功能调节

A Systems Biology Approach Identifies a R2R3 MYB Gene Subfamily with Distinct and Overlapping Functions in Regulation of Aliphatic Glucosinolates 1. 1. 1 2 1 2 Ida Elken Sønderby , Bjarne Gram Hansen , Nanna Bjarnholt , Carla Ticconi , Barbara Ann Halkier , Daniel J. Kliebenstein * 1 Plant Biochemistry Laboratory, Department of Plant Biology, Center for Molecular Plant Physiology (PlaCe), Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark, 2 Department of Plant Sciences, University of California at Davis, Davis, California, United States of America Background. Glucosinolates are natural metabolites in the order Brassicales that defend plants against both herbivores and pathogens and can attract specialized insects. Knowledge about the genes controlling glucosinolate regulation is limited. Here, we identify three R2R3 MYB transcription factors regulating aliphatic glucosinolate biosynthesis in Arabidopsis by combining several systems biology tools. Methodology/Principal Findings. MYB28 was identified as a candidate regulator of aliphatic glucosinolates based on its co-localization within a genomic region controlling variation both in aliphatic glucosinolate content (metabolite QTL) and in transcript level for genes involved in the biosynthesis of aliphatic glucosinolates (expression QTL), as well as its co-expression with genes in aliphatic glucosinolate biosynthesis. A phylogenetic analysis with the R2R3 motif of MYB28 showed that it and two homologues, MYB29 and MYB76, were members of an Arabidopsis-specific clade that included three characterized regulators of indole glucosinolates. Over-expression of the individual MYB genes showed that they all had the capacity to inc