a retrospective overview of enterovirus infection diagnosis and molecular epidemiology in the public hospitals of marseille, france (1985–2005)肠病毒感染的回顾性综述公立医院诊断和分子流行病学的马赛,法国(1985 - 2005).pdfVIP

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a retrospective overview of enterovirus infection diagnosis and molecular epidemiology in the public hospitals of marseille, france (1985–2005)肠病毒感染的回顾性综述公立医院诊断和分子流行病学的马赛,法国(1985 - 2005).pdf

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a retrospective overview of enterovirus infection diagnosis and molecular epidemiology in the public hospitals of marseille, france (1985–2005)肠病毒感染的回顾性综述公立医院诊断和分子流行病学的马赛,法国(1985 - 2005)

A Retrospective Overview of Enterovirus Infection Diagnosis and Molecular Epidemiology in the Public Hospitals of Marseille, France (1985–2005) 1 1,2 3 1,2 2 Charlene Y. Q. Tan *, Laetitia Ninove , Jean Gaudart , Antoine Nougairede , Christine Zandotti , Laurence Thirion-Perrier1, Remi N. Charrel1,2, Xavier de Lamballerie1,2 ´ ´ 1 UMR190 Unite des Virus Emergents, Universite de la Mediterranee - Institut de Recherche pour le Developpement, Marseille, France, 2 Federation de Microbiologie, Assistance Publique-Hopitaux de Marseille, Marseille, France, 3 LERTIM EA3283, Biostatistic Research Unit, Universite de la Mediterranee, Marseille, France Abstract Human enteroviruses (HEV) are frequent human pathogens and, associated in particular with large outbreaks of aseptic meningitis. Here, we have compiled a database of clinical HEV isolates from the Public Hospitals of Marseille, from 1985 to 2005. Amongst 654 isolates that could be characterized by complete sequencing of the VP1 gene, 98% belonged to species HEV-B; the most frequently isolated serotypes were Echovirus E30, E11, E7, E6 and E4. The high incidence of E30 and the recent emergence of E13 are consistent with reports worldwide and peak HEV isolation occurred mostly in the late spring and summer months. The proportion of echoviruses has decreased across the years, while that of coxsackieviruses has increased. Stool (the most frequent sample type) allowed detection of all identified serotypes. MRC5 (Human lung fibroblasts) cell line was the most conducive cell line for HEV isolation (84.9% of 10