acquisition of human-type receptor binding specificity by new h5n1 influenza virus sublineages during their emergence in birds in egypt收购生活由新的h5n1型流感病毒受体结合特异性sublineages在鸟类出现在埃及.pdfVIP

Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt 1 1,2¤ 3 4,5 1 Yohei Watanabe *, Madiha S. Ibrahim , Hany F. Ellakany , Norihito Kawashita , Rika Mizuike , 6 6,7 4,5 6 1 Hiroaki Hiramatsu , Nogluk Sriwilaijaroen , Tatsuya Takagi , Yasuo Suzuki , Kazuyoshi Ikuta * 1 Department of Virology, Research Institute for Microbial Diseases (BIKEN), Osaka University, Osaka, Japan, 2 Department of Microbiology, Faculty of Veterinary Medicine, Alexandria University, Damanhour Branch, Egypt, 3 Department of Poultry Diseases and Hygiene, Faculty of Veterinary Medicine, Alexandria University, Edfina Branch, Egypt, 4 Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, 5 Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan, 6 Health Scientific Hills, College of Life and Health Sciences, Chubu University, Aichi, Japan, 7 Faculty of Medicine, Thammasat University (Rangsit Campus), PathumThani, Thailand Abstract Highly pathogenic avian influenza A virus subtype H5N1 is currently widespread in Asia, Europe, and Africa, with 60% mortality in humans. In particular, since 2009 Egypt has unexpectedly had the highest number of human cases of H5N1 virus infection, with more than 50% of the cases worldwide, but the basis for this high incidence has not been elucidated. A change in receptor binding affinity of the viral hemagglutinin (HA) from a2,3- to a2,6-linked sialic acid (SA) is thought to be