原创力文档adult murine skeletal muscle contains cells that can differentiate into beating cardiomyocytes in vitro成年小鼠骨骼肌包含细胞,可以分化成心肌细胞体外.pdfVIP
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adult murine skeletal muscle contains cells that can differentiate into beating cardiomyocytes in vitro成年小鼠骨骼肌包含细胞,可以分化成心肌细胞体外
Open access, freely available online PLoS BIOLOGY
Adult Murine Skeletal Muscle Contains Cells
That Can Differentiate into Beating
Cardiomyocytes In Vitro
1 1 1 1 2 2
Steve O. Winitsky , Thiru V. Gopal , Shahin Hassanzadeh , Hiroshi Takahashi Divina Gryder , Michael A. Rogawski ,
3 4 5 1*
Kazuyo Takeda , Zu X. Yu , Yu H. Xu , Neal D. Epstein
1 Molecular Physiology Section, Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America, 2 Epilepsy
Research Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America, 3 Laboratory of Molecular Cardiology, National
Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America, 4 Pathology Section, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United
States of America, 5 Electron Microscopy Core Facility, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America
It has long been held as scientific fact that soon after birth, cardiomyocytes cease dividing, thus explaining the limited
restoration of cardiac function after a heart attack. Recent demonstrations of cardiac myocyte differentiation observed
in vitro or after in vivo transplantation of adult stem cells from blood, fat, skeletal muscle, or heart have challenged
this view. Analysis of these studies has been complicated by the large disparity in the magnitude of effects seen by
different groups and obscured by the recently appreciated process of in vivo stem-cell fusion. We now show a novel
population of nonsatellite cells in adult
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