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advances in identifying beryllium sensitization and disease识别敏感铍的进步和疾病
Int. J. Environ. Res. Public Health 2010, 7, 115-124; doi:10.3390/ijerph7010115
OPEN ACCESS
International Journal of
Environmental Research and
Public Health
ISSN 1660-4601
/journal/ijerph
Review
Advances in Identifying Beryllium Sensitization and Disease
Dan Middleton 1,* and Peter Kowalski 2
1 Division of Health Studies, Agency for Toxic Substances and Disease Registry, CDC Chamblee
Campus, Building 106, 4770 Buford Highway NE Mail Stop F-57, Atlanta, GA 30341, USA
2 Division of Health Assessment and Consultation, Agency for Toxic Substances and Disease
Registry, CDC Chamblee Campus, Building 106, 4770 Buford Highway NE Mail Stop F-59,
Atlanta, GA 30341, USA; E-Mail: pek2@
* Author to whom correspondence should be addressed; E-Mail: dcm2@.
Received: 1 December 2009 / Accepted: 11 January 2010 / Published: 13 January 2010
Abstract: Beryllium is a lightweight metal with unique qualities related to stiffness,
corrosion resistance, and conductivity. While there are many useful applications, researchers
in the 1930s and l940s linked beryllium exposure to a progressive occupational lung disease.
Acute beryllium disease is a pulmonary irritant response to high exposure levels, whereas
chronic beryllium disease (CBD) typically results from a hypersensitivity response to lower
exposure levels. A blood test, the beryllium lymphocyte prolif
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