an opposite effect of the cdk inhibitor, p18ink4c on embryonic stem cells compared with tumor and adult stem cellscdk抑制剂的一个相反的效果,p18ink4c胚胎干细胞与肿瘤和成体干细胞.pdfVIP

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an opposite effect of the cdk inhibitor, p18ink4c on embryonic stem cells compared with tumor and adult stem cellscdk抑制剂的一个相反的效果,p18ink4c胚胎干细胞与肿瘤和成体干细胞.pdf

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an opposite effect of the cdk inhibitor, p18ink4c on embryonic stem cells compared with tumor and adult stem cellscdk抑制剂的一个相反的效果,p18ink4c胚胎干细胞与肿瘤和成体干细胞

An Opposite Effect of the CDK Inhibitor, p18INK4c on Embryonic Stem Cells Compared with Tumor and Adult Stem Cells 1,2,4 2,4 5 3,4 1 3,4 Yanxin Li , Rekha Pal , Li-Ying Sung , Haizhong Feng , Weimin Miao , Shi-Yuan Cheng , Cindy Tian6, Tao Cheng1,2,4* 1 State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China, 2 Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, 3 Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, 4 University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America, 5 Institute of Biotechnology, National Taiwan University, Taipei, Taiwan, 6 Center for Regenerative Biology, Department of Animal Science, University of Connecticut, Storrs, Connecticut, United States of America Abstract Self-renewal is a feature common to both adult and embryonic stem (ES) cells, as well as tumor stem cells (TSCs). The cyclin- dependent kinase inhibitor, p18INK4c, is a known tumor suppressor that can inhibit self-renewal of tumor cells or adult stem cells. Here, we demonstrate an opposite effect of p18 on ES cells in comparison with teratoma cells. Our results unexpectedly showed that overexpression of p18 accelerated the growth of mouse ES cells and embryonic bodies (EB); on the contrary, inhibited the growth of late stage teratoma. Up-regulation of ES cell markers (i.e., Oct4, Nanog, Sox2, and Rex1) were detected in both ES and EB c