原创力文档altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the wntβ-catenin antagonist chibby肺形态发生改变,上皮细胞分化和力学在老鼠wntβ-catenin拮抗剂chibby不足.pdfVIP
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altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the wntβ-catenin antagonist chibby肺形态发生改变,上皮细胞分化和力学在老鼠wntβ-catenin拮抗剂chibby不足
Altered Lung Morphogenesis, Epithelial Cell
Differentiation and Mechanics in Mice Deficient in the
Wnt/b-Catenin Antagonist Chibby
1,2 1,2 3,4. 1,2. 1
Damon Love , Feng-Qian Li , Michael C. Burke , Benjamin Cyge , Masao Ohmitsu , Jeffrey
1 5 6 5 1,2,4
Cabello , Janet E. Larson , Steven L. Brody , J. Craig Cohen , Ken-Ichi Takemaru *
1 Department of Pharmacological Sciences, SUNY at Stony Brook, Stony Brook, New York, United States of America, 2 Graduate Program in Molecular and Cellular
Pharmacology, SUNY at Stony Brook, Stony Brook, New York, United States of America, 3 Medical Scientist Program (MSTP), SUNY at Stony Brook, Stony Brook, New York,
United States of America, 4 Graduate Program in Genetics, SUNY at Stony Brook, Stony Brook, New York, United States of America, 5 Section of Neonatology, Department
of Pediatrics, SUNY at Stony Brook, Stony Brook, New York, United States of America, 6 Division of Pulmonary and Critical Care, Department of Internal Medicine,
Washington University School of Medicine, St. Louis, Missouri, United States of America
Abstract
The canonical Wnt/ b-catenin pathway plays crucial roles in various aspects of lung morphogenesis and regeneration/repair.
Here, we examined the lung phenotype and function in mice lacking the Wnt/b-catenin antagonist Chibby (Cby). In support
of its inhibitory role in canonical Wnt signaling, expression of b-catenin target genes is elevated in the Cby2/ 2 lung. Notably,
Cby protein is prominently associated with the centrosome/basal body microtubule structures in embryonic l
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