analysing dynamical behavior of cellular networks via stochastic bifurcations通过随机分岔分析蜂窝网络的动力学行为.pdfVIP

Analysing Dynamical Behavior of Cellular Networks via Stochastic Bifurcations 1,2 ¨ 2,3 4 1 Anna Zakharova *, Jurgen Kurths , Tatyana Vadivasova , Aneta Koseska 1 Center for Dynamics of Complex Systems, University of Potsdam, Potsdam, Germany, 2 Potsdam Institute for Climate Impact Research, Potsdam, Germany, 3 Institute of Physics, Humboldt University Berlin, Berlin, Germany, 4 Saratov State University, Saratov, Russia Abstract The dynamical structure of genetic networks determines the occurrence of various biological mechanisms, such as cellular differentiation. However, the question of how cellular diversity evolves in relation to the inherent stochasticity and intercellular communication remains still to be understood. Here, we define a concept of stochastic bifurcations suitable to investigate the dynamical structure of genetic networks, and show that under stochastic influence, the expression of given proteins of interest is defined via the probability distribution of the phase variable, representing one of the genes constituting the system. Moreover, we show that under changing stochastic conditions, the probabilities of expressing certain concentration values are different, leading to different functionality of the cells, and thus to differentiation of the cells in the various types. Citation: Zakharova A, Kurths J, Vadivasova T, Koseska A (2011) Analysing Dynamical Behavior of Cellular Networks via Stochastic Bifurcations. PLoS ONE 6(5): e19696. doi:10.1371/journal.pone.0019696 Editor: Kumar Selvarajoo, Keio University, Japan Received December 17, 2010; Accepted April 13, 2011; Published May 25, 2011 Copyright: 2011 Zakharova et al. This is an open-acce