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apoptotic effects of chrysin in human cancer cell lines白杨素在人类癌症细胞株凋亡的影响
Int. J. Mol. Sci. 2010, 11, 2188-2199; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
Apoptotic Effects of Chrysin in Human Cancer Cell Lines
Boon Yin Khoo *, Siang Ling Chua and Prabha Balaram
Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 USM,
Penang, Malaysia; E-Mails: siang_ling85@ (S.L.C.); prabha@kb.usm.my (P.B.)
* Author to whom correspondence should be addressed; E-Mail: boonyin@usm.my;
Tel.: +604-653-4819; Fax: +604-653-4803.
Received: 23 March 2010; in revised form: 3 May 2010 / Accepted: 6 May 2010 /
Published: 19 May 2010
Abstract: Chrysin is a natural flavonoid currently under investigation due to its important
biological anti-cancer properties. In most of the cancer cells tested, chrysin has shown to
inhibit proliferation and induce apoptosis, and is more potent than other tested flavonoids
in leukemia cells, where chrysin is likely to act via activation of caspases and inactivation
of Akt signaling in the cells. Moreover, structure-activity relationships have revealed that
the chemical structure of chrysin meets the key structural requirements of flavonoids for
potent cytotoxicity in leukemia cells. It is possible that combination therapy or modified
chrysin could be more potent than single-agent use or administration of unmodified chrysin.
This study may help to develop ways of improving the effe
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