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application of magnetic nanoparticles to gene delivery磁性纳米颗粒的应用基因传递
Int. J. Mol. Sci. 2011, 12, 3705-3722; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
Application of Magnetic Nanoparticles to Gene Delivery
Daisuke Kami 1,*, Shogo Takeda 2, Yoko Itakura 1, Satoshi Gojo 1, Masatoshi Watanabe 2
1
and Masashi Toyoda
1 Research Team for Vascular Medicine, Tokyo Metropolitan Institute of Gerontology,
35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan; E-Mails: yitakura@tmig.or.jp (Y.I.);
satoshigojo-tky@umin.ac.jp (S.G.); mtoyoda@tmig.or.jp (M.T.)
2 Laboratory for Medical Engineering, Division of Materials and Chemical Engineering, Yokohama
National University, 79-1 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan;
E-Mails: smilesnow1987@ (S.T.); mawata@ynu.ac.jp (M.W.)
* Author to whom correspondence should be addressed; E-Mail: dkami@tmig.or.jp;
Tel.: +81-3-3964-3241; Fax: +81-3-3579-4776.
Received: 6 May 2011; in revised form: 18 May 2011 / Accepted: 25 May 2011 /
Published: 7 June 2011
Abstract: Nanoparticle technology is being incorporated into many areas of molecular
science and biomedicine. Because nanoparticles are small enough to enter almost all areas
of the body, including the circulatory system and cells, they have been and continue to be
exploited for basic biomedical research as well as clinical diagnostic and therapeutic
applications. For example, nanoparticles hold gr
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