arabidopsis riba proteins two out of three isoforms have lost their bifunctional activity in riboflavin biosynthesis拟南芥三分之二的瑞芭蛋白亚型已经失去了核黄素生物合成双功能活动.pdfVIP
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arabidopsis riba proteins two out of three isoforms have lost their bifunctional activity in riboflavin biosynthesis拟南芥三分之二的瑞芭蛋白亚型已经失去了核黄素生物合成双功能活动
Int. J. Mol. Sci. 2012, 13, 14086-14105; doi:10.3390/ijms131114086
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Arabidopsis RIBA Proteins: Two out of Three Isoforms Have
Lost Their Bifunctional Activity in Riboflavin Biosynthesis
1 2 1 2
Hanna-Maija Hiltunen , Boris Illarionov , Boris Hedtke , Markus Fischer and
Bernhard Grimm 1,*
1 Institute of Biology/Plant Physiology, Humboldt University Berlin, Philippstr. 13,
Building 12, D-10115 Berlin, Germany; E-Mails: hannamaijahiltunen@ (H.-M.H.);
boris.hedtke@rz.hu-berlin.de (B.H.)
2 Hamburg School of Food Science, Institute of Food Chemistry, University Hamburg,
Grindelallee 117, 20146 Hamburg, Germany; E-Mails: illarion@chemie.uni-hamburg.de (B.I.);
markus.fischer@chemie.uni-hamburg.de (M.F.)
* Author to whom correspondence should be addressed; E-Mail: bernhard.grimm@biologie.hu-berlin.de;
Tel.: +49-30-2093-6119; Fax: +49-30-2093-6337.
Received: 11 September 2012; in revised form: 3 October 2012 / Accepted: 17 October 2012 /
Published: 31 October 2012
Abstract: Riboflavin serves as a precursor for flavocoenzymes (FMN and FAD) and is
essential for all living organisms. The two committed enzymatic steps of riboflavin
biosynthesis are performed in plants by bifunctional RIBA enzymes comprised of GTP
c
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