arginase activities and global arginine bioavailability in wild-type and apoe-deficient mice responses to high fat and high cholesterol diets精氨酸酶的活动和全球精氨酸生物利用度在野生型和apoe-deficient老鼠反应高脂肪和高胆固醇的饮食.pdfVIP

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arginase activities and global arginine bioavailability in wild-type and apoe-deficient mice responses to high fat and high cholesterol diets精氨酸酶的活动和全球精氨酸生物利用度在野生型和apoe-deficient老鼠反应高脂肪和高胆固醇的饮食.pdf

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arginase activities and global arginine bioavailability in wild-type and apoe-deficient mice responses to high fat and high cholesterol diets精氨酸酶的活动和全球精氨酸生物利用度在野生型和apoe-deficient老鼠反应高脂肪和高胆固醇的饮食

Arginase Activities and Global Arginine Bioavailability in Wild-Type and ApoE-Deficient Mice: Responses to High Fat and High Cholesterol Diets 1,2 3 1,2 1 Aaron Erdely *, Diane Kepka-Lenhart , Rebecca Salmen-Muniz , Rebecca Chapman , Tracy 1,2 4 1{ 3 Hulderman , Michael Kashon , Petia P. Simeonova , Sidney M. Morris Jr. 1Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America, 2 Laboratory for Occupational Cardiovascular Toxicology, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America, 3 Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America, 4 Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America Abstract Increased catabolism of arginine by arginase is increasingly viewed as an important pathophysiological factor in cardiovascular disease, including atherosclerosis induced by high cholesterol diets. Whereas previous studies have focused primarily on effects of high cholesterol diets on arginase expression and arginine metabolism in specific blood vessels, there is no information regarding the impact of lipid diets on arginase activity or arginine bioavailability at a systemic level. We, therefore, evaluated the effects of high fat (HF) and high fat-high cholesterol (HC) diets on arginase activity in plasm