reactivation of latent tuberculosis in cynomolgus macaques infected with siv is associated with early peripheral t cell depletion and not virus load重新激活潜伏性结核病的猕猴猕猴感染猴免疫缺陷病毒与早期周边t细胞耗竭而不是病毒负荷.pdfVIP

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2017-09-09 发布于上海
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reactivation of latent tuberculosis in cynomolgus macaques infected with siv is associated with early peripheral t cell depletion and not virus load重新激活潜伏性结核病的猕猴猕猴感染猴免疫缺陷病毒与早期周边t细胞耗竭而不是病毒负荷.pdf

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reactivation of latent tuberculosis in cynomolgus macaques infected with siv is associated with early peripheral t cell depletion and not virus load重新激活潜伏性结核病的猕猴猕猴感染猴免疫缺陷病毒与早期周边t细胞耗竭而不是病毒负荷

Reactivation of Latent Tuberculosis in Cynomolgus Macaques Infected with SIV Is Associated with Early Peripheral T Cell Depletion and Not Virus Load 1. 1. 2 2 1 Collin R. Diedrich , Joshua T. Mattila , Edwin Klein , Chris Janssen , Jiayao Phuah , Timothy J. 3 3 4 1 Sturgeon , Ronald C. Montelaro , Philana Ling Lin , JoAnne L. Flynn * 1 Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, 2 Division of Laboratory Animal Resources, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, 3 Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, 4 Department of Pediatrics, Children’s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America Abstract HIV-infected individuals with latent Mycobacterium tuberculosis (Mtb) infection are at significantly greater risk of reactivation tuberculosis (TB) than HIV-negative individuals with latent TB, even while CD4 T cell numbers are well preserved. Factors underlying high rates of reactivation are poorly understood and investigative tools are limited. We used cynomolgus macaques with latent TB co-infected with SIVmac251 to develop the first animal model of reactivated TB in HIV-infected humans to better explore these factors. All latent animals developed reactivated TB following SIV infection, with a variable time to reactivation (up to 11 months post-SIV). Reactivation was independent of virus load but co