reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain活性氧产量正向和反向线粒体呼吸链电子通量.pdfVIP

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reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain活性氧产量正向和反向线粒体呼吸链电子通量.pdf

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reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain活性氧产量正向和反向线粒体呼吸链电子通量

Reactive Oxygen Species Production by Forward and Reverse Electron Fluxes in the Mitochondrial Respiratory Chain 1,2 3 4 3 Vitaly A. Selivanov , Tatyana V. Votyakova *, Violetta N. Pivtoraiko , Jennifer Zeak , Tatiana 5 3 6 1 Sukhomlin , Massimo Trucco , Josep Roca , Marta Cascante * 1 Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, and IBUB, Barcelona, Spain, 2 A. N. Belozersky Institute of Physico- Chemical Biology, Moscow State University, Moscow, Russia, 3 Department of Pediatrics, University of Pittsburgh School of Medicine and Children’s Hospital of Pittsburgh, Diabetes Institute, Pittsburgh, Pennsylvania, United States of America, 4 Neuropathology Division, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, 5 Institute of Theoretical and Experimental Biophysics, Pushchino, Russia, 6 Hospital Clinic, IDIBAPS, CIBERES, Universitat de Barcelona, Barcelona, Catalunya, Spain Abstract Reactive oxygen species (ROS) produced in the mitochondrial respiratory chain (RC) are primary signals that modulate cellular adaptation to environment, and are also destructive factors that damage cells under the conditions of hypoxia/ reoxygenation relevant for various systemic diseases or transplantation. The important role of ROS in cell survival requires detailed investigation of mechanism and determinants of ROS production. To perform such an investigation we extended our rule-based model of complex III in order to account for electron transport in the whole RC coupled to proton translocation, transme