readthrough acetylcholinesterase is increased in human liver cirrhosis在人类肝硬化readthrough乙酰胆碱酯酶增加.pdfVIP
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readthrough acetylcholinesterase is increased in human liver cirrhosis在人类肝硬化readthrough乙酰胆碱酯酶增加
Readthrough Acetylcholinesterase Is Increased in Human
Liver Cirrhosis
´ ´ ´ 1,2,3 ´ 4 1,2 ´ 4,5 ´
Marıa-Salud Garcıa-Ayllon *, Cristina Millan , Carol Serra-Basante , Ramon Bataller , Javier Saez-
Valero1,2*
´ ´ ´
1 Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez-CSIC, San Juan de Alicante, Spain, 2 Centro de Investigacion Biomedica en Red sobre
´
Enfermedades Neurodegenerativas (CIBERNED), San Juan de Alicante, Spain, 3 Unidad de Investigacion, Hospital General Universitario de Elche, Elche, Spain, 4 Liver Unit,
´ ` ´ `
Hospital Clınic, Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, 5 Centro de Investigacion Biomedica en Red de Enfermedades
´
Hepaticas y Digestivas (CIBERehd), Barcelona, Spain
Abstract
Background Aims: There have been many studies on plasma butyrylcholinesterase in liver dysfunction. However, no data
is available about acetylcholinesterase in human cirrhosis, although profound changes have been described in cirrhotic rat
models.
Methods: Human serum and liver acetylcholinesterase and its molecular forms were determined enzymatically, after
butyrylcholinesterase immunodepletion. The dist
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