原创力文档re-evaluate the effect of hyperbaric oxygen therapy in cancer - a preclinical therapeutic small animal model study重新评估高压氧治疗癌症的效果,临床治疗小动物模型研究.pdfVIP
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re-evaluate the effect of hyperbaric oxygen therapy in cancer - a preclinical therapeutic small animal model study重新评估高压氧治疗癌症的效果,临床治疗小动物模型研究
Re-Evaluate the Effect of Hyperbaric Oxygen Therapy in
Cancer - A Preclinical Therapeutic Small Animal Model
Study
1 1 2 3 4
Sneha Pande , Amit Sengupta *, Anurag Srivastava , Rajiv P. Gude , Arvind Ingle
1 Bioengineering Laboratory, Advanced Centre for Treatment, Research Education in Cancer, TATA Memorial Centre, New Mumbai, Maharashtra, India, 2 Department of
Cancer Surgery, All India Institute of Medical Science, New Delhi, India, 3 Gude Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, TATA
Memorial Centre, New Mumbai, Maharashtra, India, 4 Laboratory Animal Facilities, Advanced Centre for Treatment, Research and Education in Cancer, TATA Memorial
Centre, New Mumbai, Maharashtra, India
Abstract
Tumor hypoxia is a known driver of angiogenesis that also facilitates tumor growth. Moreover, poorly oxygenated central
tumor area remains relatively radio or chemo resistant. HBO therapy is known to elevate the levels of dissolved oxygen and
eliminates tumor hypoxia. It has been one of the modalities in cancer treatment; therefore its optimization is important. In
this experimental study, no cancer enhancing effect was seen during the course of HBO therapy; however, post therapy
there was an accelerated growth and progression of tumor. HBO treated mice lived shorter and the response to therapy was
dose tumor volume dependent. HBO therapy probably exert its effect on the cancer proliferating cells through multiple
pathways such as increased DNA damage, apoptosis geno-toxicity leading to slow cancer progression while post therapy
tumorigenic effect could be due to impaired DNA repair mechanism, mutagenic effect aneuploidy as well as altered blood
supply nutrients. Tumor growth reached plateau with time and this finding validated theoretical model pre
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