原创力文档re-expression of igf-ii is important for beta cell regeneration in adult mice表达igf-ii是重要的在成年小鼠β细胞再生.pdfVIP
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re-expression of igf-ii is important for beta cell regeneration in adult mice表达igf-ii是重要的在成年小鼠β细胞再生
Re-Expression of IGF-II Is Important for Beta Cell
Regeneration in Adult Mice
1. 2. 1 2 3 4
Luxian Zhou , Stella Pelengaris , Sylvie Abouna , James Young , David Epstein , Julia Herold , Tim
4 1 2
Wilhelm Nattkemper , Hassan Nakhai , Michael Khan *
1 School of Life Sciences, University of Warwick, Coventry, United Kingdom, 2 Warwick Medical School, University of Warwick, Coventry, United Kingdom, 3 Department of
Mathematics, University of Warwick, Coventry, United Kingdom, 4 Biodata Mining Group, Bielefeld University, Bielefeld, Germany
Abstract
Background: The key factors which support re-expansion of beta cell numbers after injury are largely unknown. Insulin-like
growth factor II (IGF-II) plays a critical role in supporting cell division and differentiation during ontogeny but its role in the
adult is not known. In this study we investigated the effect of IGF-II on beta cell regeneration.
Methodology/Principal Findings: We employed an in vivo model of ‘switchable’ c-Myc-induced beta cell ablation, pIns-c-
MycERTAM, in which 90% of beta cells are lost following 11 days of c-Myc (Myc) activation in vivo. Importantly, such ablation
is normally followed by beta cell regeneration once Myc is deactivated, enabling functional studies of beta cell regeneration
in vivo. IGF-II was shown to be re-expressed in the adult pancreas of pIns-c-MycERTAM/IGF-II+/+ (MIG) mice, following beta
cell injury. As expected in the presence of IGF-II beta cell mass and numbers recover rapidly after ablation. In contrast, in
pIns-c-MycERTAM/IGF-II+/ 2 (MIGKO) mice, which express no IGF-II, recovery of beta cell mass and numbers were delayed and
imp
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