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Open access, freely available online Research Digest Synopses of Research Articles Nicotine Keeps Leaf-Loving that are linked to the target gene and with nonmutant cultivated plants, in Herbivores at Bay that might affect resistance as well. southwestern Utah, N. attenuata’s native The tools of genetic engineering habitat. A subset of the plants was also DOI: 10.1371/journal.pbio.0020250 have largely overcome such limitations, treated with a chemical known to increase Sooner or later, a gardener looking for allowing scientists far greater control both nicotine content and resistance to “nontoxic” ways to control the inevitable and specifi city. Following this approach, herbivore attack. Predictably, several of the attack on a favorite plant will discover Ian Baldwin and colleagues use plant’s natural insect enemies made an the nicotine remedy. Steep a cup of transgenic silencing (which introduces appearance. Untreated nicotine-defi cient loose tobacco in a gallon of water, let gene “constructs” into an organism transgenic plants fared the worst, losing it sit overnight, strain, and spray away. to inactivate a gene of interest) to twice as much foliage to herbivores Caterpillars, aphids, and a diverse array of