原创力文档regional dissemination of a trimethoprim-resistance gene cassette via a successful transposable element地区传播trimethoprim-resistance基因盒通过成功的转座因子.pdfVIP
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regional dissemination of a trimethoprim-resistance gene cassette via a successful transposable element地区传播trimethoprim-resistance基因盒通过成功的转座因子
Regional Dissemination of a Trimethoprim-Resistance
Gene Cassette via a Successful Transposable Element
1. 1. 1. 2 1
Amy S. Labar , Jennifer S. Millman , Ellen Ruebush , Japheth A. Opintan , Rima A. Bishar , A.
3 2 4 1
Oladipo Aboderin , Mercy J. Newman , Adebayo Lamikanra , Iruka N. Okeke *
1 Department of Biology, Haverford College, Haverford, Pennsylvania, United States of America, 2 Department of Microbiology, University of Ghana Medical School, Accra,
Ghana, 3 Department of Medical Microbiology and Parasitology, Obafemi Awolowo University, Ile-Ife, Nigeria, 4 Department of Pharmaceutics, Obafemi Awolowo
University, Ile-Ife, Nigeria
Abstract
Background: Antimicrobial resistance is a growing international problem. We observed a 50% increase in the prevalence of
trimethoprim resistance among fecal Escherichia coli from healthy Nigerian students between 1998 and 2005, a trend to
increase that continued in 2009.
Methods and Findings: A PCR-based screen revealed that 131 (43.1%) of isolates obtained in Nigeria in 2005 and 2009
carried integron-borne dfrA cassettes. In the case of 67 (51.1%) of these isolates, the cassette was a class 1-integron-borne
dfrA7 gene, which has been reported at high prevalence from E. coli isolates from other parts of Africa. Complete
sequencing of a 27 Kb dfrA7-bearing plasmid from one isolate located the dfrA7 gene within a Tn21-type transposon. The
transposon also contained an IS26-derived bla/sul/str element, encoding resistance to b-lactams, sulphonamides and
streptomycin, an
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