原创力文档schistosoma mansoni infections in young children when are schistosome antigens in urine, eggs in stool and antibodies to eggs first detectable曼氏裂体吸虫感染儿童尿液是血吸虫抗原时,鸡蛋在凳子和鸡蛋第一抗体检测.pdfVIP
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schistosoma mansoni infections in young children when are schistosome antigens in urine, eggs in stool and antibodies to eggs first detectable曼氏裂体吸虫感染儿童尿液是血吸虫抗原时,鸡蛋在凳子和鸡蛋第一抗体检测
Schistosoma mansoni Infections in Young Children:
When Are Schistosome Antigens in Urine, Eggs in Stool
and Antibodies to Eggs First Detectable?
1 1,2 1 3 3
J. Russell Stothard *, Jose C. Sousa-Figuereido , Martha Betson , Moses Adriko , Moses Arinaitwe ,
3 3 3
Candia Rowell , Fred Besiyge , Narcis B. Kabatereine
1 Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, United Kingdom, 2 Department of Infectious and Tropical
Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, 3 Vector Control Division, Ministry of Health, Kampala, Uganda
Abstract
Background: In Uganda, control of intestinal schistosomiasis with preventive chemotherapy is typically focused towards
treatment of school-aged children; the needs of younger children are presently being investigated as in lakeshore
communities very young children can be infected. In the context of future epidemiological monitoring, we sought to
compare the detection thresholds of available diagnostic tools for Schistosoma mansoni and estimate a likely age of first
infection for these children.
Methods and Findings: A total of 242 infants and preschool children (134 boys and 108 girls, mean age 2.9 years, minimum
5 months and maximum 5 years) were examined from Bugoigo, a well-known disease endemic village on Lake Albert.
Schistosome antigens in urine, eggs in stool and host antibodies to eggs were inspected to reveal a general prevalence of
47.5% (CI95 41.1–54.0%), as ascertained by a positive criterion from at least one diagnostic method. Although c
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