schizophrenia and violence systematic review and meta-analysis精神分裂症和暴力的系统回顾和荟萃分析.pdfVIP

Schizophrenia and Violence: Systematic Review and Meta-Analysis 1 1 1 1 2 Seena Fazel *, Gautam Gulati , Louise Linsell , John R. Geddes , Martin Grann 1 Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom, 2 Centre for Violence Prevention, Karolinska Institute, Stockholm, Sweden Prison and Probation Service Head Office, Norrkoping, Sweden Abstract Background: Although expert opinion has asserted that there is an increased risk of violence in individuals with schizophrenia and other psychoses, there is substantial heterogeneity between studies reporting risk of violence, and uncertainty over the causes of this heterogeneity. We undertook a systematic review of studies that report on associations between violence and schizophrenia and other psychoses. In addition, we conducted a systematic review of investigations that reported on risk of homicide in individuals with schizophrenia and other psychoses. Methods and Findings: Bibliographic databases and reference lists were searched from 1970 to February 2009 for studies that reported on risks of interpersonal violence and/or violent criminality in individuals with schizophrenia and other psychoses compared with general population samples. These data were meta-analysed and odds ratios (ORs) were pooled using random-effects models. Ten demographic and clinical variables were extracted from each study to test for any observed heterogeneity in the risk estimates. We identified 20 individual studies reporting data from 18,423 individuals with schizophrenia and other psychoses. In men, ORs for the comparison of violence in those with schizophrenia and other psychoses with those without ment