schizophrenia as failure of left hemispheric dominance for the phonological component of language精神分裂症作为失败的左半球语言的语音组件.pdfVIP

Schizophrenia as Failure of Left Hemispheric Dominance for the Phonological Component of Language 1,2 1 3 4 5 Alessandro Angrilli *, Chiara Spironelli , Thomas Elbert , Timothy J. Crow , Gianfranco Marano , Luciano Stegagno1 1 Department of General Psychology, University of Padova, Padova, Italy, 2 CNR Institute of Neuroscience, Padova, Italy, 3 Center for Psychiatry, Reichenau and Department of Psychology, University of Konstanz, Konstanz, Germany, 4 SANE POWIC, Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom, 5 Center for Eating Disorders, ULSS 18, Rovigo, Italy Abstract Background: T. J. Crow suggested that the genetic variance associated with the evolution in Homo sapiens of hemispheric dominance for language carries with it the hazard of the symptoms of schizophrenia. Individuals lacking the typical left hemisphere advantage for language, in particular for phonological components, would be at increased risk of the typical symptoms such as auditory hallucinations and delusions. Methodology/Principal Findings: Twelve schizophrenic patients treated with low levels of neuroleptics and twelve matched healthy controls participated in an event-related potential experiment. Subjects matched word-pairs in three tasks: rhyming/phonological, semantic judgment and word recognition. Slow evoked potentials were recorded from 26 scalp electrodes, and a laterality index was computed for anterior and posterior regions during the inter stimulus interval. During phonological processing individuals with schizophrenia failed to achieve the left hemispheric dominance consi