secondary attack rate of tuberculosis in urban households in kampala, uganda续发率的肺结核在坎帕拉城市家庭中,乌干达.pdfVIP

Secondary Attack Rate of Tuberculosis in Urban Households in Kampala, Uganda 1 2 1 3 4 Christopher C. Whalen *, Sarah Zalwango , Allan Chiunda , LaShaunda Malone , Kathleen Eisenach , 2 3 5 Moses Joloba , W. Henry Boom , Roy Mugerwa 1 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia, United States of America, 2 Tuberculosis Research Unit, Makerere University, Kampala, Uganda, 3 Department of Medicine, Case Western Reserve University, School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio, United States of America, 4 Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, 5 Department of Medicine, Makerere University Medical School, Kampala, Uganda Abstract Background: Tuberculosis is an ancient disease that continues to threaten individual and public health today, especially in sub-Saharan Africa. Current surveillance systems describe general risk of tuberculosis in a population but do not characterize the risk to an individual following exposure to an infectious case. Methods: In a study of household contacts of infectious tuberculosis cases (n = 1918) and a community survey of tuberculosis infection (N = 1179) in Kampala, Uganda, we estimated the secondary attack rate for tuberculosis disease and tuberculosis infection. The ratio of these rates is the likelihood of progressive primary disease after recent household infection. Results: The secondary attack rate for tuberculosis disease was 3.0% (95% confidence