single nucleotide polymorphism in gene encoding transcription factor prep1 is associated with hiv-1-associated dementia单核苷酸多态性基因编码转录因子prep1 hiv-1-associated痴呆.pdfVIP

Single Nucleotide Polymorphism in Gene Encoding Transcription Factor Prep1 Is Associated with HIV-1- Associated Dementia 1. 1. ¨ 1 1 2 Sebastiaan M. Bol , Thijs Booiman , Danielle van Manen , Evelien M. Bunnik , Ard I. van Sighem , 1 1 2,3 1 Margit Sieberer , Brigitte Boeser-Nunnink , Frank de Wolf , Hanneke Schuitemaker , Peter 4,5 1 ´ 1 Portegies , Neeltje A. Kootstra , Angelique B. van ’t Wout * 1 Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infection and Immunity Amsterdam (CINIMA) at the Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands, 2 HIV Monitoring Foundation, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands, 3 Department of Infectious Disease Epidemiology, Imperial College, London, United Kingdom, 4 Department of Neurology at the Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands, 5 Department of Neurology at the OLVG Hospital, Amsterdam, The Netherlands Abstract Background: Infection with HIV-1 may result in severe cognitive and motor impairment, referred to as HIV-1-associated dementia (HAD). While its prevalence has dropped significantly in the era of combination antiretroviral therapy, milder neurocognitive disorders persist with a high prevalence. To identify additional therapeutic targets for treating HIV- associated neurocognitive disorders, several candidate g