single nucleotide polymorphisms of tcf7l2 are linked to diabetic coronary atherosclerosistcf7l2的单核苷酸多态性与糖尿病患者冠状动脉粥样硬化有关.pdfVIP

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single nucleotide polymorphisms of tcf7l2 are linked to diabetic coronary atherosclerosistcf7l2的单核苷酸多态性与糖尿病患者冠状动脉粥样硬化有关.pdf

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single nucleotide polymorphisms of tcf7l2 are linked to diabetic coronary atherosclerosistcf7l2的单核苷酸多态性与糖尿病患者冠状动脉粥样硬化有关

Single Nucleotide Polymorphisms of TCF7L2 Are Linked to Diabetic Coronary Atherosclerosis 1,2 1,2,3 1,2 1 Axel Muendlein , Christoph H. Saely , Simone Geller-Rhomberg , Gudrun Sonderegger , Philipp Rein1,2,3, Thomas Winder1,2,3, Stefan Beer1,2,3, Alexander Vonbank1,2,3, Heinz Drexel1,2,3,4* 1Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria, 2 Private University of the Principality of Liechtenstein, Triesen, Principality of Liechtenstein, 3 Department of Medicine and Cardiology, Academic Teaching Hospital Feldkirch, Feldkirch, Austria, 4 Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America Abstract Background: Coronary artery disease (CAD) shares common risk factors with type 2 diabetes (T2DM). Variations in the transcription factor 7-like 2 (TCF7L2) gene, particularly rs7903146, increase T2DM risk. Potential links between genetic variants of the TCF7L2 locus and coronary atherosclerosis are uncertain. We therefore investigated the association between TCF7L2 polymorphisms and angiographically determined CAD in diabetic and non-diabetic patients. Methodology/Principal Findings: We genotyped TCF7L2 variants rs7903146, r and r in a cross- sectional study including 1,650 consecutive patients undergoing coronary angiography for the evaluation of established or suspected stable CAD. Significant CAD was diagnosed in the presence of coronary stenoses $50%. Variant rs7903146 in the total study cohort was significantly associated with significant CAD (adjusted additive OR = 1.29 [1.09–1.53]; p = 0.003). This association was strong and significant in T2DM patients (n