serologic survey of the pandemic h1n1 2009 virus in guangdong province, china a cross sectional study2009年h1n1流感大流行病毒的血清学调查广东省,中国一项横断面研究.pdfVIP

Serologic Survey of the Pandemic H1N1 2009 Virus in Guangdong Province, China: A Cross Sectional Study Xin Zhang*., Jianfeng He., Linghui Li., Xiaolan Zhu, Changwen Ke, Hanzhong Ni, Nianmei Hou, Haojie Zhong, Jie Wu Center for Disease Control and Prevention of Guangdong Province, Guangzhou, People’s Republic of China Abstract Background: Relying on surveillance of clinical cases limits the ability to understand the full impact and severity of an epidemic, which urges a deep insight into the serological evidence of infection and transmission feature of pandemic H1N1 2009 (pH1N1) virus in Guangdong province. Methods: In this cross-sectional serological survey, serum samples were collected by multi-stage stratified random sampling in Jan 2010. Antibody titers were measured by hemagglutination inhibition (HI) assay. Age-specific and region-specific prevalence were calculated based on the results of HI assay (positive, HI titer$1:40). Results: A total of 4,319 serum samples had been collected from subjects without vaccination with pH1N1 vaccine. The seroprevalence was 22.82% (985/4,319). By contrast, there was a marked spatial heterogeneity in prevalence. The seroprevalence was 27.3% in large city, 21.4% in medium cities, higher than that of 20.2% in rural areas. The seroprevalence was highest in 11–20 age group (32.8%), however, in those above 60 years of age group, which was 12.6%, lower than other age groups. On the other hand, antibody titers to pH1N1 virus were highest in school children, which were followed by a gradual decrease in adult. However, in the elderly groups from cities, especially from large city, the antibody titer to pH1N1 increased significantly and reached a much higher level. Conclusion: Our results showed that the prevalence for pH1N1 was correlated with age and population density. Pree