原创力文档seropositivity to herpes simplex virus antibodies and risk of alzheimers disease a population-based cohort study单纯疱疹病毒血清阳性抗体和阿尔茨海默氏症的风险以人群为基础的队列研究.pdfVIP
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seropositivity to herpes simplex virus antibodies and risk of alzheimers disease a population-based cohort study单纯疱疹病毒血清阳性抗体和阿尔茨海默氏症的风险以人群为基础的队列研究
Seropositivity to Herpes Simplex Virus Antibodies and
Risk of Alzheimer’s Disease: A Population-Based Cohort
Study
1,2 ´ ` 1,2 ´ 2,3 2,3 1,2
Luc Letenneur *, Karine Peres , Herve Fleury , Isabelle Garrigue , Pascale Barberger-Gateau ,
1,2 1,2 4 1,2
Catherine Helmer , Jean-Marc Orgogozo , Serge Gauthier , Jean-Franc¸ois Dartigues
1 INSERM, U897, Bordeaux, France, 2 Universite Victor Segalen Bordeaux 2, Bordeaux, France, 3 Universite Victor Segalen Bordeaux 2, Laboratoire de Virologie, Bordeaux,
France, 4 McGill University, Centre for Studies in Aging, Montreal, Quebec, Canada
Abstract
Background: Herpes Simplex Virus (HSV) infection has been proposed as a possible risk factor of Alzheimer’s Disease (AD)
notably because it is neurotropic, ubiquitous in the general population and able to establish lifelong latency in the host. The
fact that HSV was present in elderly subjects with AD suggests that the virus could be a co-factor of the disease. We
investigated the risk of developing AD in anti-HSV immunoglobulin G (IgG) positive subjects (indicator of a lifelong infection
to HSV) and IgM-positive subjects (indicator of primary infection or reactivation of the virus) in a longitudinal population-
based cohort of elderly subjects living in the community.
Methods: Cox proportional hazard models were used to study the risk of developing AD according to the presence or not of
anti-HSV IgG and IgM antibodies, assessed in the sera of 512 elderly initially free of dementia followed for 14 years.
Results: Dur
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