seroprevalence of measles-, mumps- and rubella-specific igg antibodies in german children and adolescents and predictors for seronegativityseroprevalence麻疹、流行性腮腺炎和rubella-specific免疫球蛋白抗体seronegativity德国儿童和青少年和预测.pdfVIP

Seroprevalence of Measles-, Mumps- and Rubella- Specific IgG Antibodies in German Children and Adolescents and Predictors for Seronegativity ¨ 1 2 Christina Poethko-Muller *, Annette Mankertz 1 Department of Epidemiology and Health Reporting, Robert Koch Institute, Berlin, Germany, 2 Division of Viral Infections; National Reference Center MMR and RRL WHO EURO, Robert Koch Institute, Berlin, Germany Abstract We have undertaken a seroprevalence study with more than 13,000 children, who had been included in the German KIGGS survey, a representative sample of children and adolescents 0–17 years of age. The IgG titres against measles, mumps and rubella were determined in 1 to 17 year olds While 88.8% of the children were MMR-vaccinated at least once, 76.8% of children aged 1 to 17 years showed prevalence of antibodies to MMR. The highest seronegativity was seen with respect to mumps. Gender differences were most pronounced with regard to rubella IgG titres: girls aged 14 to 17 years were best protected, although seronegativity in 6.8% of this vulnerable group still shows the need of improvement. Search for predictors of missing seroprevalence identified young age to be the most important predictor. Children living in the former West and children born outside of Germany had a higher risk of lacking protection against measles and rubella, while children with a migration background but born in Germany were less often seronegative to measles antibodies than their German contemporaries. An association of seronegativity and early vaccination was seen for measles but not for mumps and rubella. A high maternal educational level was associated with seronegativity to measles and rubella. In vaccinated children, seronegativity was highest for mumps and lowest for rubella