原创力文档serotonin augments gut pacemaker activity via 5-ht3 receptors5 -羟色胺增强肠道起搏器通过5-ht3受体的活动.pdfVIP
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serotonin augments gut pacemaker activity via 5-ht3 receptors5 -羟色胺增强肠道起搏器通过5-ht3受体的活动
Serotonin Augments Gut Pacemaker Activity via 5-HT3
Receptors
1 3 2 1 4 1¤
Hong-Nian Liu , Susumu Ohya , Yuji Nishizawa , Kenta Sawamura , Satoshi Iino , Mohsin Md Syed ,
1 3 1
Kazunori Goto , Yuji Imaizumi , Shinsuke Nakayama *
1 Department of Cell Physiology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2 Department of Anatomy and Cell Biology, Nagoya University Graduate
School of Medicine, Nagoya, Japan, 3 Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya,
Japan, 4 Department of Anatomy, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
Abstract
Serotonin (5-hydroxytryptamine: 5-HT) affects numerous functions in the gut, such as secretion, muscle contraction, and
enteric nervous activity, and therefore to clarify details of 5-HT’s actions leads to good therapeutic strategies for gut
functional disorders. The role of interstitial cells of Cajal (ICC), as pacemaker cells, has been recognised relatively recently. We
thus investigated 5-HT actions on ICC pacemaker activity. Muscle preparations with myenteric plexus were isolated from the
murine ileum. Spatio-temporal measurements of intracellular Ca2+ and electric activities in ICC were performed by
employing fluorescent Ca2+ imaging and microelectrode array (MEA) systems, respectively. Dihydropyridine (DHP) Ca2+
antagonists and tetrodotoxin (TTX) were applied to suppress smooth muscle and nerve activities, respectively. 5-HT
si
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