原创力文档seroprevalence of pertussis in senegal a prospective study塞内加尔seroprevalence百日咳的前瞻性研究.pdfVIP
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seroprevalence of pertussis in senegal a prospective study塞内加尔seroprevalence百日咳的前瞻性研究
Seroprevalence of Pertussis in Senegal: A Prospective
Study
1,2 2 4 1,2 1
Lobna Gaayeb *, Jean Biram Sarr , Mamadou O. Ndiath , Jean-Baptiste Hanon , Anne-Sophie Debrie ,
2 1,2 ´ 5 1,2,3 1,2
Modou Seck , Anne-Marie Schacht , Franck Remoue , Emmanuel Hermann , Gilles Riveau
1 Centre for Infection and Immunity of Lille (CIIL) - U1019 Inserm, UMR8204 CNRS, Institut Pasteur de Lille, Lille, France, 2 Biomedical Research Centre EPLS, Saint-Louis,
´
Senegal, 3 Universite Lille Nord de France, Lille, France, 4 Laboratoire de Paludologie, UMR198 URMITE, IRD Campus international de Hann, Dakar, Senegal, 5 UMR
´
MIVEGEC – IRD224-CNRS5290-Universite de Montpellier 1 et 2- IRD – Centre de Recherche Entomologique de Cotonou (CREC), Cotonou, Benin
Abstract
Background: Pertussis, also known as whooping cough, is a vaccine-preventable respiratory disease caused by Bordetella
pertussis infection, against which Senegalese children are immunized with the diphtheria-tetanus-whole cell pertussis
vaccine (DTwP). Seroepidemiology of pertussis has been widely described in industrialized countries, but rare are the
studies referring to it in developing countries.
Methods: We conducted a longitudinal survey in Northern Senegal to investigate the epidemiology of B. pertussis by
evaluating the IgG antibody (Ab) response against pertussis toxin (PT). A cohort of 410 children aged 1 to 9
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