serotonin receptor expression in human prefrontal cortex balancing excitation and inhibition across postnatal development5 -羟色胺受体表达在人类前额叶皮层在产后发展平衡激励和抑制.pdfVIP

Serotonin Receptor Expression in Human Prefrontal Cortex: Balancing Excitation and Inhibition across Postnatal Development 1,2 3,4,5 6 3,4,5 Evelyn K. Lambe *, Stu G. Fillman , Maree J. Webster , Cynthia Shannon Weickert 1 Department of Physiology, University of Toronto, Toronto, Ontario, Canada, 2 Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada, 3 Schizophrenia Research Institute, Sydney, New South Wales, Australia, 4 Schizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, New South Wales, Australia, 5 Faculty of Medicine, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia, 6 Stanley Medical Research Institute, Rockville, Maryland, United States of America Abstract Serotonin and its receptors (HTRs) play critical roles in brain development and in the regulation of cognition, mood, and anxiety. HTRs are highly expressed in human prefrontal cortex and exert control over prefrontal excitability. The serotonin system is a key treatment target for several psychiatric disorders; however, the effectiveness of these drugs varies according to age. Despite strong evidence for developmental changes in prefrontal Htrs of rodents, the developmental regulation of HTR expression in human prefrontal cortex has not been examined. Using postmortem human prefrontal brain tissue from across postnatal life, we investigated the expression of key serotonin receptors with distinct inhibitory (HTR1A, HTR5A) and excitatory (HTR2A, HTR2C, HTR4, HTR6) effects on cortical neurons, including two receptors which appear to be expressed to a greater degree in inhibitory interneurons of cerebral cortex (HTR2C, HTR6). We found distinct devel