serotonin and depression a disconnect between the advertisements and the scientific literature5 -羟色胺和抑郁的广告和科学文献之间的脱节.pdfVIP

Open access, freely available online Essay Serotonin and Depression: A Disconnect between the Advertisements and the Scientifi c Literature Jeffrey R. Lacasse, Jonathan Leo* n the United States, selective what some pharmaceutical companies levels of serotonin metabolites in serotonin reuptake inhibitor (SSRI) have sought to overcome with their the cerebrospinal fl uid of clinically Iantidepressants are advertised advertising campaigns. For example, depressed suicidal patients to controls, directly to consumers [1]. These Pfi zer’s television advertisement for but the primary literature is mixed and highly successful direct-to-consumer the antidepressant sertraline (Zoloft) plagued with methodological diffi culties advertising (DTCA) campaigns have stated that depression is a serious such as very small sample sizes and largely revolved around the claim that medical condition that may be due to uncontrolled confounding variables. SSRIs correct a chemical imbalance a chemical imbalance, and that “Zoloft In a recent review of these studies, caused by a lack of serotonin (see works to correct this imbalance” [5]. the chairman of the German Medical Tables 1 and 2). For instance, sertraline Other SSRI advertising campaigns Board and colleagues stated, “Reported (Zoloft) was the sixth best-selling have also claimed that depression associations of subgroups of suicidal medication in the US in 2004, with is linked with