seroprevalence of pandemic (h1n1) 2009 in pregnant women in china an observational studyseroprevalence 2009年h1n1流感大流行的孕妇在中国一项观察性研究.pdfVIP

Seroprevalence of Pandemic (H1N1) 2009 in Pregnant Women in China: An Observational Study 1. 1. 1. 1 1 1 1 1 Xiang Huo , Xian Qi , Fenyang Tang , Rongqiang Zu , Liang Li , Bin Wu , Yuanfang Qin , Hong Ji , 1 1 1 2 1 1 1 Jianguang Fu , Shenjiao Wang , Hua Tian , Zhibin Hu , Haitao Yang , Minghao Zhou , Hua Wang , Fengcai Zhu1* 1Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, China, 2 College of Public Health, Nanjing Medical University, Nanjing, China Abstract Background: We investigated the seropositive rates and persistence of antibody against pandemic (H1N1) 2009 virus (pH1N1) in pregnant women and voluntary blood donors after the second wave of the pandemic in Nanjing, China. Methodology/Principal Findings: Serum samples of unvaccinated pregnant women (n = 720) and voluntary blood donors (n = 320) were collected after the second wave of 2009 pandemic in Nanjing. All samples were tested against pH1N1 strain (A/California/7/2009) with hemagglutination inhibition assay. A significant decline in seropositive rates, from above 50% to about 20%, was observed in pregnant women and voluntary blood donors fifteen weeks after the second wave of the pandemic. A quarter of the samples were tested against a seasonal H1N1 strain (A/Brisbane/59/2007). The antibody titers against pH1N1 strain were found to correlate positively with those against seasonal H1N1 strain. The correlation was modest but statistically significant. Conclusions and Significance: The high seropositive rates in both pregnant women and volu