原创力文档seroprevalence of angiostrongylus cantonensis in wild rodents from the canary islands的摘要cantonensis seroprevalence野生啮齿动物从加那利群岛.pdfVIP
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seroprevalence of angiostrongylus cantonensis in wild rodents from the canary islands的摘要cantonensis seroprevalence野生啮齿动物从加那利群岛
Seroprevalence of Angiostrongylus cantonensis in Wild
Rodents from the Canary Islands
´ 1 1 ´ 1 2
Aaron Martin-Alonso , Pilar Foronda *, Marıa Antonieta Quispe-Ricalde , Carlos Feliu , Basilio
Valladares1
˜
1 University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, La Laguna, Islas Canarias, Espana, 2 Department of Microbiology
˜ ˜
and Parasitology, University of Barcelona, Barcelona, Cataluna, Espana
Abstract
Background: Angiostrongylus cantonensis is a lungworm of rats (Muridae) that is the causative agent of human cerebral
angiostrongyliasis. The life cycle of A. cantonensis involves rats and mollusks as the definitive and intermediate hosts,
respectively. This study was designed to increase the knowledge about the occurrence and distribution of A. cantonensis in
its definitive host in the Canary Islands, using parasitological and serological analysis in different areas and age groups.
Methodology/Principal Findings: Between 2009 and 2010, 54 black rats (Rattus rattus) from Tenerife were captured from
six human-inhabited areas and sera samples were obtained. The lung nematodes were identified by morphological and
molecular tools as A. cantonensis. The 31-kDa glycoprotein antigen was purified from A. cantonensis adult worms by
electrophoresis and electroelution. Of
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