seroprevalence and risk factors for coxiella burnetii (q fever) seropositivity in dairy goat farmers households in the netherlands, 2009–2010seroprevalence伯纳特氏立克次氏体和风险因素(q热病)血清阳性乳制品山羊农民家庭在荷兰,2009 - 2010.pdfVIP

Seroprevalence and Risk Factors for Coxiella burnetii (Q Fever) Seropositivity in Dairy Goat Farmers’ Households in The Netherlands, 2009–2010 1 1,2 3 2 4 Barbara Schimmer , Anke Lenferink , Peter Schneeberger , Helen Aangenend , Piet Vellema , 2 1 Jeannine Hautvast , Yvonne van Duynhoven * 1 Centre for Infectious Disease Control, National Institute for Public Health and The Environment, Bilthoven, The Netherlands, 2 Academic Collaborative Centre AMPHI, Department of Primary and Community Care, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 3 Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, ’s-Hertogenbosch, The Netherlands, 4 Department of Small Ruminant Health, Animal Health Service, Deventer, The Netherlands Abstract Community Q fever epidemics occurred in the Netherlands in 2007–2009, with dairy goat and dairy sheep farms as the implicated source. The aim of the study was to determine the seroprevalence and risk factors for seropositivity in dairy goat farmers and their household members living or working on these farms. Sera of 268 people living or working on 111 dairy goat farms were tested for Coxiella burnetii IgG and IgM antibodies using immunofluorescence assay. Seroprevalences in farmers, spouses and children (12–17 years) were 73.5%, 66.7%, and 57.1%, respectively. Risk factors for seropositivity were: performing three or more daily goat-related tasks, farm location in the two southern provinces of the country, proximity to bulk milk-positive farms, distance from the nearest stable to residence of 10 meters or less, presence of cats and multiple goat breeds in the stable, cover