sequestration and tissue accumulation of human malaria parasites can we learn anything from rodent models of malaria封存和组织积累的人类疟原虫疟疾从啮齿动物模型,我们能学到什么.pdfVIP

Review Sequestration and Tissue Accumulation of Human Malaria Parasites: Can We Learn Anything from Rodent Models of Malaria? Blandine Franke-Fayard, Jannik Fonager, Anneke Braks, Shahid M. Khan, Chris J. Janse* Leiden Malaria Research Group, Department of Parasitology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands states in rodents such as cerebral complications in several strains of Abstract: The sequestration of Plasmodium falciparum– mice [18–23], pregnancy-associated pathology [24–26], and acute infected red blood cells (irbcs) in the microvasculature of lung injury [27,28]. To what extent these different pathologies organs is associated with severe disease; correspondingly, observed in laboratory animals are representative for human the molecular basis of irbc adherence is an active area of pathology is a matter of debate and has been discussed in a study. In contrast to P. falciparum, much less is known number of review papers [8,9,19,21,25,26,29–33]. Based on a about sequestration in other Plasmodium parasites, number of differences in clinical features of human cerebral including those species that are used as models to study malaria (HCM) caused by P. falciparum and the cerebral pathology severe malaria. Here, we review the cytoadherence of P. berghei infections in mice, the relevance of P. berghei f