seasonal genetic influence on serum 25-hydroxyvitamin d levels a twin study季节性的遗传影响血清双胞胎研究的25 -羟基维生素d浓度.pdfVIP

Seasonal Genetic Influence on Serum 25-Hydroxyvitamin D Levels: A Twin Study 1 ˚ 2,3 3,4 3 5 Greta Snellman *, Hakan Melhus , Rolf Gedeborg , Sylvia Olofsson , Alicja Wolk , Nancy L. 6 ¨ 1,3 Pedersen , Karl Michaelsson 1 Department of Surgical Sciences, Section of Orthopaedics, University Hospital, Uppsala, Sweden, 2 Department of Medical Sciences, Section of Clinical Pharmacology, University Hospital, Uppsala, Sweden, 3 Uppsala Clinical Research Centre, University Hospital, Uppsala, Sweden, 4 Department of Surgical Sciences, Section of Anaesthesiology and Intensive Care, University Hospital, Uppsala, Sweden, 5 Department of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden, 6 Departments of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden Abstract Background: Although environmental factors, mainly nutrition and UV-B radiation, have been considered major determinants of vitamin D status, they have only explained a modest proportion of the variation in serum 25- hydroxyvitamin D. We aimed to study the seasonal impact of genetic factors on serum 25-hydroxyvitamin D concentrations. Methodology/Principal findings: 204 same-sex twins, aged 39–85 years and living at northern latitude 60u, were recruited from the Swedish Twin Registry. Serum 25-hydroxyvitamin D was analysed by high-pressure liquid chromatography and mass spectrometry. Genetic modelling techniques estimated the relative contributions of genetic, shared and individual- specific environmental factors to the variation in serum vitamin D. The average serum 25-hydroxyvitam