原创力文档role of the gp85trans-sialidases in trypanosoma cruzi tissue tropism preferential binding of a conserved peptide motif to the vasculature in vivo角色gp85trans-sialidases鲁兹锥体组织趋向性优惠绑定的守恒的体内血管肽的主题.pdfVIP
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role of the gp85trans-sialidases in trypanosoma cruzi tissue tropism preferential binding of a conserved peptide motif to the vasculature in vivo角色gp85trans-sialidases鲁兹锥体组织趋向性优惠绑定的守恒的体内血管肽的主题
Role of the gp85/Trans-Sialidases in Trypanosoma cruzi
Tissue Tropism: Preferential Binding of a Conserved
Peptide Motif to the Vasculature In Vivo
1 2 3 2
Renata R. Tonelli , Ricardo J. Giordano , Elena Magda Barbu , Ana Claudia Torrecilhas , Gerson S.
2 4 3 3 2 ´ 2
Kobayashi , Robert R. Langley , Wadih Arap , Renata Pasqualini , Walter Colli , Maria Julia M. Alves *
˜ ˜ ´ ´
1 Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 2 Departamento de Bioquımica, Instituto de Quımica,
˜ ˜
Universidade de Sao Paulo, Sao Paulo, Brazil, 3 David H. Koch Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America,
4 Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Abstract
Background: Transmitted by blood-sucking insects, the unicellular parasite Trypanosoma cruzi is the causative agent of
Chagas’ disease, a malady manifested in a variety of symptoms from heart disease to digestive and urinary tract
dysfunctions. The reasons for such organ preference have been a matter of great interest in the field, particularly because
the parasite can invade nearly every cell line and it can be found in most tissues following an infectio
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